STEM-Talk
Dawn Kernagis and Ken Ford
Categories: Health
Listen to the last episode:
Dr. Vyvyane Loh returns to STEM-Talk for her second appearance to talk about atherosclerotic heart disease. Also known as ASCVD, the disease has been reported to affect 26 million people in the U.S., and annually leads two million hospitalizations and more than 400,000 deaths.
Vyvyane is a board-certified physician in obesity and internal medicine. In episode 142 of STEM-Talk, we talked to Vyvyane about her Boston-based preventative-care practice that specializes in weight management and the treatment of chronic metabolic diseases such as diabetes, hypertension and dyslipidemia.
In today’s podcast, Vyvyane and host Dr. Ken Ford talk about ASCVD as well as recent research that has shown substantial individual variability in the response to statin therapy as a way to lower cardiovascular risk. Vyvyane and Ken also discuss how the current knowledge base informing clinical practice in medicine today is far behind advances in the biological sciences, especially in the field of ASCVD.
Show notes:
[00:03:15] Ken welcomes Vyvyane back to STEM-Talk and encourages listeners to check out Vyvyane’s first interview, episode 142. Ken goes on to mention that atherosclerotic heart disease has been reported to affect 26 million people in the U.S. and that despite the wide use of statins as a primary prevention of atherosclerotic heart disease, the effects of this treatment have been variable with regards to major adverse cardiac events. Ken asks Vyvyane for her thoughts.
[00:05:32] Ken asks Vyvyane about recent developments in atherosclerotic heart disease research, specifically in regard to the anatomical aspects of the disease-model itself.
[00:08:43] Ken follows up asking Vyvyane how the knowledge we have of glycocalyces, and the endothelial lining of the blood vessels, could affect clinical practice.
[00:12:19] Ken asks if there are any other recent updates to the anatomical model of atherosclerotic disease that people should be aware of.
[00:13:09] Ken asks Vyvyane how she would characterize the significance of the tunica intima of the coronary artery.
[00:15:25] Ken asks about the third recent anatomical highlight to blood vessels relevant to the discussion.
[00:19:19] Ken follows up, asking if this is how the vasa vasorum contributes to our understanding of the development of atherosclerosis.
[00:21:05] Ken asks Vyvyane to explain what endothelial dysfunction is and what are its downstream effects.
[00:26:09] Ken asks Vyvyane to expound on the link between atherosclerotic disease and auto-immunity.
[00:31:01] Ken asks, given the link to inflammation, if there have been any therapeutic developments made in the treatment of atherosclerotic disease.
[00:34:54] Ken asks about the vaccine that is being developed for atherosclerosis.
[00:37:53] Ken mentions that another recent development in the field is the growing appreciation for clonal hematopoiesis in atherosclerosis. Ken asks Vyvyane to explain what clonal hematopoiesis is.
[00:39:55] Ken asks Vyvyane what some actionable takeaways are from our discussion on atherosclerosis that listeners can take home with them.
[00:43:17] Ken asks Vyvyane about her passion for dance, and how much time she invests in that area of her life.
[00:48:11] Ken follows up asking Vyvyane what drives her to pursue dance so passionately.
[00:53:34] In closing the interview, Ken encourages listeners to check out Vyvyane’s podcast as well as her website.
Links:
Previous episodes
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200 - Episode 166: Vyvyane Loh and Ken Ford discuss atherosclerotic heart disease Thu, 11 Apr 2024 - 0h
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199 - Episode 165: John Edwards on ketamine treatment for depression and suicide prevention Thu, 14 Mar 2024
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198 - Episode 164: Michael Leon on olfactory stimulation as a buffer for dementia symptoms Wed, 21 Feb 2024 - 0h
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197 - Episode 163: Mark Mattson discusses glutamate, the brain’s most important neurotransmitter Wed, 31 Jan 2024
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196 - Episode 162: Marc Hamilton discusses the soleus push-up and the health hazard of excessive sitting Wed, 10 Jan 2024
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195 - Episode 161: Sten Stray-Gundersen on the benefits of blood-flow restriction training Mon, 18 Dec 2023
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194 - Episode 160: Euan Ashley on precision medicine and predicting, preventing, and diagnosing diseases Tue, 28 Nov 2023
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193 - Episode 159: Ken and Dawn discuss chatbots, termites, kratom, ketosis, and the future of AI Mon, 06 Nov 2023 - 0h
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192 - Episode 158: Judith Curry talks about the uncertainties of climate change Thu, 05 Oct 2023 - 0h
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191 - Episode 157: Don Layman on the role of dietary protein in muscle, health, and disease Thu, 14 Sep 2023
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190 - Episode 156: Josh Hagen discusses optimizing performance in athletes and warfighters Mon, 21 Aug 2023
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189 - Episode 155: Chris McCurdy discusses kratom’s benefits and possible risks Thu, 20 Jul 2023
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188 - Episode 154: Orthopedic surgeon Brian Cole discusses advances in the treatment of knee, elbow and shoulder injuries Wed, 28 Jun 2023
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187 - Episode 153: Dominic D’Agostino discusses new advances in the study of nutritional ketosis Thu, 08 Jun 2023
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186 - Episode 152: Mark Shelhamer talks about the effects of spaceflight on humans and NASA’s Planned Mars Mission Tue, 16 May 2023
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185 - Episode 151: John Ioannidis talks about the bungled response to COVID-19 Wed, 19 Apr 2023
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184 - Episode 150: Barbara Thorne talks about E.O. Wilson, the conehead termite and the sociality of termites Tue, 21 Mar 2023
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183 - Episode 149: Jeff Volek discusses ketogenic diet to improve metabolic health and treat disease Tue, 21 Feb 2023
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182 - Episode 148: Ed Weiler on the Hubble and James Webb space telescopes, Mars rovers and NASA’s search for life Mon, 30 Jan 2023
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181 - Episode 147: Gwen Bryan talks about advances in wearable robotic devices and exoskeletons Wed, 04 Jan 2023 - 0h
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180 - Episode 146: Dan Pardi talks about behaviors to improve healthspan Thu, 15 Dec 2022
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179 - Episode 145: Ken answers questions about hypersonic flight, sentient AI, ketogenic vs Mediterranean diets, and more Wed, 30 Nov 2022 - 0h
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178 - Episode 144: Jason Fung on how fasting and a low-carb diet improve insulin resistance and metabolic health Wed, 09 Nov 2022
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177 - Episode 143: Ben Bikman on the roles of insulin and ketones in metabolic function Wed, 12 Oct 2022
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176 - Episode 142: Vyvyane Loh on weight management, ketogenic diet, and the treatment of metabolic diseases Wed, 21 Sep 2022
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175 - Episode 141: Jeff Iliff on newly discovered system that clears waste from the brain Thu, 01 Sep 2022
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174 - Episode 140: Kaleen Lavin on the benefits of exercise on Parkinson’s and “inflammaging” Wed, 10 Aug 2022
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173 - Episode 139: Matt Kaeberlein discusses healthspan, longevity, and rapamycin Mon, 25 Jul 2022
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172 - Episode 138: Mark Lewis discusses hypersonics and the importance of research in national defense Wed, 06 Jul 2022
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171 - Episode 137: Greg Potter discusses lifestyle changes for better health and sounder sleep Mon, 13 Jun 2022
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170 - Episode 136: Greg Potter talks about circadian biology and the importance of sleep Wed, 11 May 2022
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169 - Episode 135: Elaine Lee discusses human performance, resilience and healthspan Tue, 19 Apr 2022
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168 - Episode 134: Mike Griffin discusses America’s hypersonic arms race with Russia and China Mon, 28 Mar 2022
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167 - Episode 133: Mark Mattson talks about the benefits and science of intermittent fasting Wed, 23 Feb 2022
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166 - Episode 132: Martin Kulldorff discusses vaccines, lockdowns, school closings and the global response to COVID-19 Mon, 24 Jan 2022
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165 - Episode 131: Christopher Logothetis discusses advances in prostate cancer therapies Mon, 13 Dec 2021
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164 - Episode 130: Josh Turknett talks about holistic approaches that help people end chronic migraines Thu, 04 Nov 2021
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163 - Episode 129: Morley Stone talks about biomimetics and human performance augmentation Thu, 14 Oct 2021 - 0h
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162 - Episode 128: Tommy Wood talks about high-fat diets and the metabolic flexibility of the human gut Thu, 23 Sep 2021
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161 - Episode 127: From UFOs to fasting to the keto flu, Ken & Dawn answer questions Wed, 25 Aug 2021 - 0h
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160 - Episode 126: Christoffer Clemmensen discusses therapeutic strategies to correct obesity and its disorders Wed, 04 Aug 2021
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159 - Episode 125: Gary Taubes addresses common arguments used against ketogenic diets Wed, 14 Jul 2021
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158 - Episode 124: Gary Taubes makes a case for the ketogenic diet and its metabolic benefits Wed, 23 Jun 2021 - 0h
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157 - Episode 123: Steve Chien talks about AI, Mars rovers, and the possibility of intelligent alien life Wed, 26 May 2021 - 0h
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156 - Episode 122: James Kirkland on targeting senescent cells to reverse age-related diseases Thu, 06 May 2021 - 0h
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155 - Episode 121: Pascal Lee on the Mars mission and our search for alien life in the galaxy Wed, 14 Apr 2021
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154 - Episode 120: Gordon Lithgow on alpha-ketoglutarate’s potential to affect healthspan and lifespan Wed, 17 Mar 2021 - 0h
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153 - Episode 119: Gordon Lithgow talks about the biology of aging and prolonging lifespan Thu, 25 Feb 2021 - 0h
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152 - Episode 118: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases Tue, 02 Feb 2021 - 0h
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151 - Episode 117: Julie Andersen talks about her research into aging and neurodegenerative diseases Tue, 12 Jan 2021 - 0h